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Dangerous Synthetic Cannabinoids

Certain synthetic cannabinoids fall under a designer drug category, often sprayed onto other plant matter to be consumed through smoking. These are very chemically different from the safe synthetic cannabinoids replicating THC and CBD, among others. Often marketed as an herbal incense or “herbal smoking blend,” and even taking the dangerous name of Synthetic Marijuana, […]

Safe Synthetic Cannabinoids

Synthetic versions of THC and CBD, such as dronabinol and Epidiolex, are perfectly healthy and safe synthetic cannabinoids. These syntheses are exact copies of THC and CBD, and so behave in the same way when binding to CB1 and CB2 receptors. They are not chemically identical to other, much more dangerous synthetic cannabinoids, such as […]

Other Phytocannabinoid-Producing Plants

Though widely regarded as unique to cannabis, there are a few other plants capable of producing their own phytocannabinoids that likewise interact with our endocannabinoid system. Many of these chemicals are technically lipophilic alkamides, but their interactions with cannabinoid receptors make them qualify as phytocannabinoids themselves. Hops Most surprisingly, a species of hops known as […]

Unstudied Phytocannabinoids

Though detected in cannabis, dozens of phytocannabinoids have not yet been studied for their effects or interactions in the endocannabinoid system. These include cannabichromenenic acid (CBCa), cannabichromanone (CBCN), cannabichromevarin (CBCV) a propyl analogue of CBC, cannabinodiol (CBDL), cannabidivarinic acid (CBDVa) a propyl analogue of CBDa, cannabielsoin (CBE) an artifact derived from CBD, cannabigerol monomethyl ether […]

CBN

Cannabinol (CBN) is a nonenzymatic breakdown product of THC and THCV exposed to UV light and oxygen, and is commonly found in aged cannabis. Discovered in 1940 by Roger Adams, it is a partially psychotropic, psychoactive phytocannabinoid typically used as an indicator of how fresh a dried bud is, but is also known to be […]

CBC

Cannabichromene (CBC) is a psychoactive non-psychotropic phytocannabinoid. It was discovered in 1964 and is the decarboxylated form of CBCa found in heated juvenile cannabis. As the plant matures, the CBC levels lower, but GW Pharmaceutical was able to develop a mutated Cannabis sativa variety that has difficulties producing THC and CBD, allowing the CBC to […]

CBDV

Cannabidivarin (CBDV)  is a psychoactive, non-psychotropic decarboxylated propyl analogue phytocannabinoid of CBD found in heated cannabis. It was discovered in 1964 as a homologue to CBD, and is not a CB1 agonist but appears to activate and desensitize the vanilloid TRPV1. Preliminary research suggests CBDV is what helps differentiate strains bred specifically for treating seizure […]

CBD

Cannabidiol (CBD) is the decarboxylated phytocannabinoid of CBDa found in heated cannabis. It was discovered in 1940 by Roger Adams and is the second most abundant phytocannabinoid found in cannabis. Because it mostly affects CB2 receptors instead of CB1, it produces no psychotropic effects, and its medicinal uses can be felt immediately. Any strain containing […]

CBDa

Cannabidiolic acid (CBDa) is a psychoactive, non-psychotropic acidic precursor to CBD found in raw cannabis. CBDa predominantly binds to CB2 receptors, but like CBD, can interact with 5-HT1a serotonin receptors as well. Long-term use of CBDa has shown it to provide subtle relief of varying symptoms over time, between 3 days and 4 weeks. How […]

THCV

Tetrahydrocannabivarin (THCV) is the decarboxylated propyl analogue phytocannabinoid of THCVa found in heated cannabis, and a homologue to THC. It was discovered in 1964 and is a high-energy and relatively abundant psychoactive non-psychotropic phytocannabinoid. It seems to mimic CBD’s anxiety relief, and recent research has shown it to be fairly effective in appetite-suppression, lending to […]

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