Caryophyllene (β-caryophyllene, caryophyllene oxide), a peppery, spicy, woody smelling sesquiterpene, actually interacts with CB2 receptors, technically making it a cannabinoid itself. A good vaporization temperature for getting the most out of this terpene is 118°C (246°F). It also has a phytocannabinoid-terpene effect which is known to help with pain, depression, addiction and anxiety. Combining this terpene with THC has a synergistic chemical reaction on the cannabinoid receptors in the brain. They both bind to CB2 receptors and, when combined, have a therapeutic, calming effect. Caryophyllene begins to replace the THC molecules in your brain, lowering your high drastically and helping you regain your composure. Caryophyllene occurs naturally in black pepper, cloves, cinnamon, rosemary, hops, basil and cotton.
Caryophyllene in particular has been shown to assist with arthritis, PTSD, nausea, gastro-protection, hampering ulcers and combating autoimmune disorders. Strains with caryophyllene include Hash Plant, Tahoe OG Kush, Girl Scout Cookies and ACDC.
- Tambe, Y. Tsujiuchi, H. Honda, G. Ikeshiro, Y. Tanaka, S. Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene. Planta Medica. (1996)
- Legault, J. Pichette, A. Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel. Journal of Pharmacy and Pharmacology. (2007)
- Gertsch, J. Leonti, M. Raduner, S. Racz, I. Chen, JZ. Xie, XQ. Altmann, KH. Karsak, M. Zimmer, A. Beta-caryophyllene is a dietary cannabinoid. Proceedings of the National Academy of Sciences of the USA. (2008)
- Bento, AF. Marcon, R. Dutra, RC. Claudino, RF. Cola, M. Leite, DFP. Calixto, JB. β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway. American Journal of Pathology. (2011)