Cannabidiolic acid (CBDa) is a psychoactive, non-psychotropic acidic precursor to CBD found in raw cannabis. CBDa predominantly binds to CB2 receptors, but like CBD, can interact with 5-HT1a serotonin receptors as well. Long-term use of CBDa has shown it to provide subtle relief of varying symptoms over time, between 3 days and 4 weeks. How […]
Tetrahydrocannabivarin (THCV) is the decarboxylated propyl analogue phytocannabinoid of THCVa found in heated cannabis, and a homologue to THC. It was discovered in 1964 and is a high-energy and relatively abundant psychoactive non-psychotropic phytocannabinoid. It seems to mimic CBD’s anxiety relief, and recent research has shown it to be fairly effective in appetite-suppression, lending to […]
What is THC Tetrahydrocannabinol (THC) is the decarboxylated phytocannabinoid of THCa and a precursor to CBN found in heated cannabis. It is the dominant psychoactive, psychotropic phytocannabinoid in cannabis, and was discovered in 1940 by Roger Adams. It’s the reason we feel euphoric, happy and hungry after consumption. Today, most cannabis strains have a THC […]
What is THCa Tetrahydrocannabinolic acid (THCa) is a psychoactive, non-psychotropic acidic precursor to THC, CBNa and CBN found in raw cannabis. THCa doesn’t appear to interact with either CB1 or CB2 receptors, and research is sparse in terms of its effects. Raw cannabis leaves are popularly juiced or brewed into teas for their THCa content. […]
What is CBGVa Cannabigerovarinic acid (CBGVa) is a psychoactive, non-psychotropic acidic propyl analogue phytocannabinoid of CBGa found in raw cannabis. Similarly to CBGa, it is a naturally-occurring compound and a building block for other phytocannabinoids. Through a process of biosynthesis, it produces THCVa, CBDVa and CBCVa. CBGVa in particular has been shown to assist with […]
What Is CBG Cannabigerol (CBG) is the decarboxylated phytocannabinoid of CBGa found in heated cannabis. It is a psychoactive, non-psychotropic “stem cell” phytocannabinoid, and alongside its precursor CBGa was discovered in 1964. During cannabis’ growth, the majority of CBG is converted into other phytocannabinoids, and most strains rarely have any more than 1% of its […]
What Is CBGa Cannabigerolic acid (CBGa) is a psychoactive, non-psychotropic acidic precursor to CBG found in raw cannabis. Called the mother of all phytocannabinoids, it is the primary phytocannabinoid in carboxylated cannabis and is considered the stem cell phytocannabinoid, first discovered in 1964 and later isolated and synthesized in 1975. Synthases, natural enzymes in cannabis, […]
Phytocannabinoids in the Plant To date, over 113 phytocannabinoids have been identified within the cannabis plant, the only known plant to produce phytocannabinoids in such large amounts. These phytocannabinoids can rarely form with a 3 carbon ring opposed to a 5 carbon ring, making them propyl phytocannabinoids. THC and CBD are the two most common […]
Serotonin System and its Function The serotonin system is a major neuronal system that plays a role in various mental functions, including the regulation of anxiety, mood, cognition, perception and pain. Serotonin works by binding to 5-HT receptors, of which 14 variants have been identified, though full understanding of what each one does has not […]
The Dopaminergic System The reinforcement and reward models of drug addiction have suggested that dopamine neurotransmission plays a key role in the motivation to use drugs. Dopamine appears to be at least partially responsible for the stimulus-reward association that is involved in addiction, and abnormal dopamine levels have even been correlated with schizophrenic and psychotic […]
