Cannabidiolic acid (CBDa) is a psychoactive, non-psychotropic acidic precursor to CBD found in raw cannabis. CBDa predominantly binds to CB2 receptors, but like CBD, can interact with 5-HT1a serotonin receptors as well. Long-term use of CBDa has shown it to provide subtle relief of varying symptoms over time, between 3 days and 4 weeks.
How CBDa Assists
CBDa in particular has been shown to assist with asthma, ALS, Lou Gehrig’s disease, anxiety, OCD, stress, cancer, bronchitis, inflammatory bowel disease, irritable bowel syndrome, Crohn’s disease, ulcerative colitis and nausea.
Citations
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- Bolognini, D. Rock, EM. Cluny, NL. Cascio, MG. Limebeer, CL. Duncan, M. Stott, CG. Javid, FA. Parker, LA. Pertwee, RG. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. British Journal of Pharmacology. (2013)
- Takeda, S. Okazaki, H. Ikeda, E. Abe, S. Yoshioka, Y. Watanabe, K. Aramaki, H. Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells. Journal of Toxicological Sciences. (2014)
- Miller, S. Understanding Cannabinoids – CBDa and CBD. Green Flower. (2018)
- Cannabinoid Acids like THCa and CBDa. Green Flower. (2018)